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Sunday, May 10, 2020 | History

2 edition of in-vivo distribution of anti-thymocyte serum. found in the catalog.

in-vivo distribution of anti-thymocyte serum.

Hugh Oliver O"Kane

in-vivo distribution of anti-thymocyte serum.

by Hugh Oliver O"Kane

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Published .
Written in English


Edition Notes

Thesis (M. Ch.)--The Queens" University of Belfast, 1969.

The Physical Object
Pagination1 v
ID Numbers
Open LibraryOL19929342M

The main protection against virus-induced disease is the immune system. This chapter provides a brief overview of the adaptive immune response and discusses its relevance to picornavirus infection. The immune response can be classified in several ways, but it may be most logical to do so by antigen specificity. Thus, immune responses may be termed non-antigen-specific or antigen-specific Cited by: 8. Anti‐thymocyte globulins (ATGs) are polyclonal immunoglobulin G used for the in vivo T‐cell depletion of grafts. The addition of ATG to the conditioning regimen may reduce the incidence of graft‐versus‐host disease (GVHD) but is associated with delayed immune reconstitution.

A key determinant for the survival of an organism is the ability to recognize and respond to invading pathogens without damaging host tissues. This is accomplished largely by the concerted activity of the innate and adaptive branches of the immune system, which efficiently eliminate invading pathogens and restore tissue homeostasis. An initial step in the generation of robust immune responses Cited by: The effect of Thymectomy and anti-Thymocyte serum on the immunological competence of adult mice. Eur. J. Immunol., CrossRef Google Scholar Waltenbaugh, C., Thèze, J. and Benacerraf, B., Restriction of primary responses to the IgG class and dependency of IgM response on secondary immunisation for the co-polymers of L-glutamic acid Author: Sarah Howie.

Resistance to secondary infection by Schistosoma mansoni was measured in mice whose T-cell responses had been ablated or modified [reduced?]. The method used to measure resistance to reinfection was to perfuse mice 3 weeks after the secondary infection, at which time the schistosomes from the secondary infection are morphologically distinguishable from those of the primary by: Titel: Creating the most powerful in vivo environment for cord blood cell therapies Auteur(s): Boelens JJ Publicatiedatum: Titel: CD4+ Reconstitution and Event Free Survival Are Predicted By Low ATG Exposure after Cord Blood Transplantation in Children: Towards Individualized ATG Dosing to Improve Survival Chances Auteur(s): Boelens.


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In-vivo distribution of anti-thymocyte serum by Hugh Oliver O"Kane Download PDF EPUB FB2

Anti-thymocyte globulin is normally given in conjunction with other (small molecule) immunosuppressants, and a major limitation to its use is the risk of infections, including bacterial, fungal, viral, and protozoal. 32,33 Reactivation of CMV is a particular concern, and has been shown to be substantially increased by the addition of anti.

Abstract. When mouse haematopoietic cells are incubated in vitro in appropriate dilutions of horse anti-mouse thymocyte serum or globulin (HAMTS or HAMTG), the number of in vitro colonies formed by such cells is increased.

There was a good correlation between the immunosuppressive potency and the colony-enhancing property of a given serum by: 1. Anti-thymocyte serum (ATS) was administered to CD-1 mice infected with Trichinella spiralis larvae and its effects on intestinal lysophospholipase (EC ) activity, peripheral blood lymphocytes and bone marrow, peripheral blood and intestinal eosinophilia were assayed in the same experimental animal.

The ATS caused a significant suppression of both the tissue lysophospholipase Cited by: 4. Robert Eisenberg, in Stiehm's Immune Deficiencies, Anti-Thymocyte Globulin. Anti-thymocyte globulin refers to formulations of immunoglobulins purified from the serum of rabbits or horses that have been immunized against human T cells.

29,30 These polyclonal preparations are broadly reactive with human lymphoid cells, and cause profound lymphopenia. 31 Two preparations are approved in the. Immunosuppressive ATS. Analysis of the effect of anti-thymocyte serum on T lymphocyte subsets.

Zimmerman B, Swain SL, Dutton RW. The effect of anti-thymocyte serum (ATS) on functional T cell subsets within the immunoregulatory network was by: 9. Polyclonal anti-thymocyte globulins (ATGs) are widely used in allogeneic stem cell transplantation (allo-SCT) for GvHD prophylaxis.

ATGs exerted anti-tumor effects in in Cited by: 1. An alternative strategy employs an in vivo T cell depletion with either monoclonal T cell-specific antibodies, like Campath1-H, 9 or with polyclonal antibodies, like anti-thymocyte globulin (ATG Cited by: Rabbit anti-thymocyte globulin induction in renal transplantation: review of the literature Leah Andress,1 Anjali Gupta,2 Nida Siddiqi,3 Kwaku Marfo2,3 1University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice, Buffalo, 2Montefiore Medical Center, The University Hospital for Albert Einstein College of Medicine Department of Abdominal Organ.

immunosuppressive potency anti-thymocyte serum anti-lymphocyte serum microsome fraction endoplasmic reticulum fraction subcellular thymocyte fraction allogenic murine tumor metastases system This research was supported in part by the research grant from the American Heart Association Northeast Ohio Chapter, by: 2.

Anti-thymocyte globulin (ATG) is widely used for in vivo T cell depletion and immunomodulation in unrelated donor (URD) stem cell transplantation (SCT) to reduce the risk of graft vs.

host disease (GVHD). However, despite the reduction in GVHD risk, outcomes are generally not superior to matched related donor (MRD) SCT conditioned without by: 2.

Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a retrospective, pharmacodynamic cohort analysis Previous Article Safety and tolerability of idelalisib, lenalidomide, and rituximab in relapsed and refractory lymphoma: the Alliance for Clinical Trials in Oncology Cited by: DESCRIPTION.

THYMOGLOBULIN® (anti-thymocyte globulin [rabbit]) is a purified, pasteurized, immunoglobulin G, obtained by immunization of rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes.

THYMOGLOBULIN is a sterile, lyophilized powder for intravenous administration after reconstitution. The in vitro generation of regulatory cells by anti-thymocyte globulins could provide ad-ditional therapeutic modalities for immune-mediated disease.

Topics: antigens, cd25, globulins, graft-versus-host disease, graft-versus-host disease, acute, immunoglobulin g, mice, oryctolagus cuniculus, regulatory t-lymphocytes, thymocytes, t Cited by: ATG in patients’ serum samples obtained 1, 2, or 3 weeks posttransplantation showed 55%, 41%, and 25% inhibition of T-cell proliferation, respectively, compared with pretransplantation serum samples, when added to phytohemagglutimin-stimulated T-cell cultures [6].

Two randomized studies of thy-moglobulin r-ATG at doses of mg/kg or 15 mg/kg. Areas covered: In this review, the authors provide an overview of the most recent approaches of T-cell depletion (TCD) including ex-vivo αβ+ TCD and in-vivo TCD with anti-thymocyte globulin (ATG).

Determine the response rate in patients with low- or intermediaterisk myelodysplastic syndromes treated with anti-thymocyte globulin and etanercept.

Correlate ex vivo and in vitro phenotypic, cytogenetic, and functional disease characteristics with in vivo response in. Homologous cells treated with an incomplete anti-c serum were also shown to be agglutinated by rabbit anti-human globulin serum.

D-positive cells only weakly agglutinated by certain anti-D sera were found to be strongly agglutinated after washing and exposing to a rabbit anti-globulin serum.

ATG should be added to myeloblative and non-myeloblative preparative regimens for haemopoietic cell transplantation when using unrelated donors. The benefits of decreases in steroid use are clinically significant.

Epstein-Barr virus reactivation is increased, but is manageable by prospective monitoring and the use of rituximab. Future trials could determine whether the doses of ATG used in Cited by: In vivo T-cell depletion with alemtuzumab [,] has proven to be a promising approach for the prevention of acute and chronic GVHD.

Anti-thymocyte globulin (ATG), introduced into the conditioning regimen for the prevention of graft rejection in patients with aplastic anemia in [ ], has become an important component for prophylactic.

@article{osti_, title = {Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice}, author = {Muranaka, M and Suzuki, S and Koizumi, K and Takafuji, S and Miyamoto, T and Ikemori, R and Tokiwa, H}, abstractNote = {The prevalence rate of allergic rhinitis caused by pollen has strikingly increased in Japan in the last three decades.

It has an oral bioavailability of 80%, protein binding of >99%, metabolism sites of the GI mucosa and liver, volume of distribution (V d) of L/kg, elimination half-life of 14–18 days and excretion routes of faeces (48%) and urine (43%).

Leflunomide metabolism. Teriflunomide is the main active in vivo metabolite of leflunomide. Upon Legal status: AU: S4 (Prescription only), CA: ℞-only. Introduction. Anti-thymocyte globulin (ATG) was implemented in the conditioning regimen in the early ’s to overcome the incidences of graft rejection and graft-versus-host-disease (GvHD) that were observed after transplantation with bone marrow (BM) or peripheral blood stem cells (PBSC) ().It however became apparent that conditioning with ATG severely affects immune reconstitution (IR Cited by: Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis.